Table 7: Cytotoxic activity of the ligand and some metal complexes against human tumor cells.
No. Compound In vitro cytotoxicity IC50 (μM)∗
MCF-7 PC3 Hela
DOX∗∗ 4.17 ± 0.2 8.87 ± 0.6 5.57 ± 0.4
1 L 7.91 ± 0.5 12.13 ± 1.0 6.83 ± 0.5
2 Pt4+ 53.26 ± 3.3 67.52 ± 3.9 62.40 ± 3.7
3 Cu2+ 14.16 ± 1.2 26.91 ± 1.7 15.27 ± 1.4
4 Cd2+ 18.02 ± 1.4 35.26 ± 2.5 22.36 ± 1.8
5 Ni2+ 9.98 ± 0.8 16.97 ± 1.3 8.14 ± 0.7
∗IC50 (μM): 1–10 (very strong). 11–20 (strong). 21–50 (moderate). 51–100 (weak) and above 100 (noncytotoxic).
∗∗DOX: Doxorubicin.