Table 7: Cytotoxic activity of the ligand and some metal complexes against human tumor cells.
No. | Compound | In vitro cytotoxicity IC50 (μM)∗ | ||
MCF-7 | PC3 | Hela | ||
DOX∗∗ | 4.17 ± 0.2 | 8.87 ± 0.6 | 5.57 ± 0.4 | |
1 | L | 7.91 ± 0.5 | 12.13 ± 1.0 | 6.83 ± 0.5 |
2 | Pt4+ | 53.26 ± 3.3 | 67.52 ± 3.9 | 62.40 ± 3.7 |
3 | Cu2+ | 14.16 ± 1.2 | 26.91 ± 1.7 | 15.27 ± 1.4 |
4 | Cd2+ | 18.02 ± 1.4 | 35.26 ± 2.5 | 22.36 ± 1.8 |
5 | Ni2+ | 9.98 ± 0.8 | 16.97 ± 1.3 | 8.14 ± 0.7 |
∗IC50 (μM): 1–10 (very strong). 11–20 (strong). 21–50 (moderate). 51–100 (weak) and above 100 (noncytotoxic). | ||||
∗∗DOX: Doxorubicin. |